progeria

Progeria!!!!

What is progeria??????

• Progeria is an “accelerated aging disease”
• Causes physical changes
• Affect 1 in 4 million (actual) and 1 in 8 million (reported) newborns
• Not caused by defective DNA repair
• It’s mutation not due to heredity

History of progeria??????

• First discovered by Jonathan Hutchinson in 1886 and Hastings Gilford.
• There have been over 100 cases of Progeria reported.

(Jonathan Hutchinson)

Causes of progeria??????

• Develops during cell division in the gametes.
• Caused by mutation in Lamin A protein on chromosome 1.
• Lamin A defects contribute to normal aging.

Symtoms!!!

• • •Progeria is an “accelerated aging disease”
  • •The word Progeria came from a Greek word means ‘prematurely old’
  • •Causes physical changes
  • •Affect 1 in 4 million (actual) and 1 in 8 million (reported) newborns
  • •Not caused by defective DNA repair
  • •It’s mutation not due to heredity

Treatments!!!!

• There is currently no treatment for this disease.
• patients usually live about 13 years.